Dear Fildtripusers, I have some time-freq EEG data from 2 Groups (25 Patients and 25 Controls). There are 2 conditions in the paradigm. I would like to do dependent sample t-test to compare conditions within Groups. Also I need independent sample t-test between the Groups. We have some preknowledge about the effects, so we want to look in already defined sensors within certain frequency and latency (no multiple comparison problem). I have difficulties finding a solution for the design matrix in the ft_freqstatistics. I am not sure if this solution for dependent sample t-test is correct? nsubj=25; cfg.design=design(1,:) = [1:nsubj 1:nsubj]; cfg.design=design(2,:) = [ones(1,nsubj) ones(1,nsubj)*2]; uvar = 1; ivar = 2; For independent sample t-test I have no idea.I couldn't find solution on the Tutorial Documentation page. Any suggestion is greatly appreciated. Thank you in advance! Nenad https://www.avast.com/sig-email?utm_medium=email&utm_source=link&utm_campaign=sig-email&utm_content=webmail&utm_term=icon Virus-free. www.avast.com https://www.avast.com/sig-email?utm_medium=email&utm_source=link&utm_campaign=sig-email&utm_content=webmail&utm_term=link <#m_-6583688795636336439_DAB4FAD8-2DD7-40BB-A1B8-4E2AA1F9FDF2>